Diabetogenic Action of Frusemide

Diabetogenic Action of Alloxan on Liver Histopathology

The cytotoxic alloxan is the most prominent diabetogenic chemical agent in experimental diabetes research. Alloxan has been found to be selectively toxic to liver hepatocytes. The experiments aim to understand the effect of alloxan on cytomorphology of liver in rat. Treatment with alloxan caused central vein congestion with significant dilatation of sinusoidal spaces. The liver of the alloxan t...

The diabetogenic action of crude anterior pituitary extracts.

Comparative Diabetogenic Action of the Hypophysis from Various Animals

Of all the anterior hypophyses tested, those of the human produced the most marked diabetogenic action in the dog with its pancreatic tissue reduced to 4 gm., and in the hypophysectomized and pancreatectomized toad. The human hypophysis also produced diabetogenic action in the normal dog on daily doses of 1.26 mg. per kilo per day for 2 days. The hypophysectomized dog with its pancreas reduced ...

Diabetogenic action of streptozotocin: relationship of dose to metabolic response.

The relationship between the dose of intravenously administered streptozotocin (a N-nitroso derivative of glucosamine) and the diabetogenic response has been explored by use of the following indices of diabetogenic action: serum glucose, urine volume, and glycosuria, ketonuria, serum immunoreactive insulin (IRI), and pancreatic IRI content. Diabetogenic activity could be demonstrated between th...

Diabetogenic effect of cyclosporin.

A young woman given a renal allograft for polycystic kidney disease developed insulin dependent diabetes mellitus 25 days after transplantation. There was no family history of diabetes, plasma glucose concentrations had been normal at presentation and on five subsequent occasions, and at no time were islet cell antibodies detectable. Plasma C peptide concentrations, however, were greatly suppre...